(Natural Inflammation Support)
(Joint Support Plus More)
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(Inflammation and Joint Support plus More*)
What is Flamatrol?
- Flamatrol supports the body’s normal inflammatory response, which is a natural
process that contributes to many reactions that go on in the body. Normal
inflammation can arise from trauma, such as a seemingly harmless bump on your
arm, to other influences such as overexertion or aging.
Support for joint discomfort and stiffness from overexertion or aging*
Bodily pain can inhibit a person from living a full and active lifestyle and
severely impact their quality of life. As the body ages or is overworked from
physical activity and lack of rest, individuals often experience greater degrees
of limited functioning due to pain issues as health issues and declining well
being may give rise to symptoms that create pain and physical impairment.
Studies indicate back pain is the most common cause of disability in the U.S.
for those under 45. Approximately 25% of strains related to back fatigue and
overuse in the work setting result in loss of workdays and productivity.1
Research indicates the vast majority of physical pain is related to
inflammation. Inflammation occurs as a response to pathogens and often when it
occurs swelling, heat, pain and redness are experienced.2 Studies
suggest inflammation occurs through two metabolic pathways that result in the
production of various compounds known as eicosanoids.3 Research
suggests if inflammation can be reduced, the frequency or degree of pain
experienced may be greatly diminished.
Directions: Roex® Flamatrol? - Is a "Pain Formula" that provides a blend of
ingredients including Meriva® Curcumin, MSM, Devil’s Claw, Frankincense, White
Willow bark extract, Myrrh and Turmeric with a recommended dose of 2-650mg
capsules twice daily that reduce pain symptoms in a natural, non-habit forming
manner that does not raise the level of risk associated with many synthetic pain
relief products that can be extremely harsh on the body and induce negative side
Meriva® Curcumin & Turmeric (Curcuma Longa)
Meriva® Curcumin is a specialized bioavailable curcumin-phosphatidylcholine
complex that aids in pain management. Curcumin, the yellow pigment in
turmeric, a hydrophobic polyphenol, has been extensively used to mediate
inflammation. Turmeric has an extensive history of use in moderating
inflammation and exhibits potent antioxidant properties.4
Its chief chemical property curcumin, embodies 90% of the entire curcuminoid matter.5
Research indicates curcumin provides anti-inflammatory benefits by,
“inhibiting pro-inflammatory enzymes such as COX and lipoxygenases,
inflammatory transcription factors, signal transducer and activator of
transcription 3, as well as their genomic expression.”6 While
the benefits of unformulated curcumin have been examined, the major
hindrance to curcumin lies in that it displays poor stability during
initial consumption phases. Research suggests once curcumin is able to
enter the plasma it is then highly stable and permeable.7
Meriva, a phytosome complexing curcumin with phosphatidylcholine was
created to provide hydrolytic stabilization, and increase oral
absorption rates greater than 29 times of unformulated curcumin.8
Myriad clinical research has been conducted providing efficacy of Meriva as a
tool for management of inflammation and pain. 50 participants over 3
months experiencing knee joint inflammatory related pain were given the
standard “best available treatment” while the treatment group also
received 1g/day of Meriva. Use resulted in a 58% decrease in WOMAC
scores including walking performance score increases from 76 at baseline
pre-trial to 332 meters post-trial. Levels of C-reactive protein, a
marker for inflammation, also decreased greatly as much as 157 mg/L
decrease. Users also showed a 63% in painkiller use decrease and 38%
decrease in experienced gastrointestinal complications after
administration of Meriva compared to controls. Results indicated the
complex not only relieved pain but also increased mobility in
participants using Meriva. The major curcuminoid in Meriva is
demethoxycurcumin, an even more potent analogue than curcumin.4,9, 10, 11
An extension of the previous study was completed, 8 months in length
with 100 participants to examine the long-term benefits of Meriva.
Results found reduction in WOMAC scores measuring pain, stiffness and
physical function limitations from baseline 80.6 to 33.3, improved
Karnofsky Performance scores, as well as inflammation markers, which all
showed reductions from Meriva use.4
Undenatured type II collagen is derived from chicken sternum cartilage,
including epitopes, and research has found it is highly efficacious in
the promotion of joint health and the reduction of joint pain and
discomfort symptoms with extended lasting benefits. UC−ΙΙ works by
prompting the deactivation of the inflammation, which is the leading
cause of pain. It prevents the breakdown of joint cartilage, in a quick
acting manner allowing the body to recover from the inflammation and
resume normal joint functioning. Clinical studies found that
administration of UC−II was more than twice as effective that use of
high quality glucosamine and chondroitin, including a 52-subject, 90-day
study with 40 mg of UC−II compared to 1,500mg of glucosamine and
1,200mg of chondroitin in the decrease of knee pain. The study also
found improvements in various scores of scales related to measurement of
joint pain and functioning, such as the WOMAC index, VAS score, and
Lesquesne index.12 A pilot study including 5 women found that
UC−II use for 42 days resulted in reduced morning stiffness and
significantly reduced pain.13 UC−II is well tolerated and GRAS.14, 15
Additional Ingredients in Flamatrol®
WhiteWillow Bark Extract (Salix alba) - White Willow
Bark extract has long been used as a mediator of pain and is the
original source from which aspirin was derived.
MSM - Methylsulfonylmethane (MSM), a naturally
occurring sulfur compound exhibits anti-inflammatory properties and
provides antioxidant support that may be able to stabilize oxidative
stress that physical activity may induce.
Devil’s Claw (Harpagophytum procumbens) – Devil’s Claw
is believed to have anti-inflammatory properties associated with
reduction in both musculoskeletal and joint related pain.
Frankincense (Boswellia serrata) &Myrrh (Commiphora
mukul) - Frankincense and myrrh, gum resins exhibiting
anti-inflammatory benefits, have an extensive history of use in
1 Gagnier JJ, van Tulder MW, Berman B, Bombardier
C. Herbal medicine for low back pain. Spine. 2007; 32(1): 82-92.
2 Su S, Yua Y, Wang Y, Gu W, Zhou W, Duan J, Jiang H, Chen T, Tang Y. Evaluation
of anti-inflammatory & analgesic properties of individual and combined extracts
from commiphora myrrha and boswellia. J of Ethnophar. 2012; 193(2): 649-656.
3 Stewart K, Cole D. The commercial harvest of devil’s claw in southern Africa:
the devil’s in the details. J of Ethnopharmacology. 2005; 100: 225-236.
4 Hoppe J. Curcuma: Turmeric. Medical Herbalism J for the Clin. Practitioner.
2001; 11(4): 3-5.
5 Epstein J, Sanderson IR, MacDonald TT. Curcumin as a therapeutic agent: The
evidence from in vitro, animal and human studies. British J of Nutrition. 2010;
6 Belcaro G, Cesarone M, Dugall M, Pellegrini L, Ledda A, Grossi M, Togni S,
Appendino G. Efficacy and safety of Meriva, a complex
curcumin-phosphatidlycholine complex, during extended administration in
osteoarthritis patients. Alternative Medicine Review. 2010; 15(4): 337-344.
7 Anand P, Kunnumakkara A, Newman R, Aggarwal B. Bioavailability of curcumin:
Problems and promises. Molecular Pharmaceutics. 2007; 4(6): 807-818.
8 Indena. Meriva bioavailable curcumin. http://www. Phytosomes.info. Accessed
January 15, 2012.
9 Belcaro G, Cesarone M, Dugall M, Pellegrini L, Ledda A, Grossi M, Togni S,
Appendino G. Product-Evaluation registry Meriva, curcumin-phosphatidylcholine
complex, for complementary management of OA. Panminerva Medica. 2010; 52(2):
10 Cuomo J, Appendino G, Dern A, Schneider E, McKinnon T, Brown M, Togni S,
Dixon B. Comparative absorption of a standardized curcuminoid mixture and its
lecithin formulation. J of Nat. Prod. 2011; 74: 664-669.
11 Heller L. Curcumin complex could provide arthritis benefits, Indena study.
Nutra Ingredients. http://nutraingredients.com/content/view/print/313516.
Accessed January 23, 2012.
12 Crowley DC, Lau FC, Sharma P, et al. Safety and efficacy of undenatured type
II collagen in the treatment of OA of the knee: A clinical trial. International
Journal of Med Sci. 2009; 6: 312-321.
13 Bagchi D, Misner B, Bagchi M, et al. Effects of orally administered
undenatured type II collagen against arthritic inflammatory diseases:Mechanistic
exploration. Int J Clin Pharm Res. 2002; 22: 101-110.
14 Marone PA, Lau FC, Gupta RC, Bagchi M, Bagchi D. Safety and toxicological
evaluations of undenatured type II collagen. Toxicol Mech Meth. 2010.
15 Burdock Group. Dossier in support of the generally recognized as safe (GRAS)
status of UC??II? as a food ingredient. Internal data, 2009. Accessed March 12,
16 Setty AR, Sigal LH. Herbal medications commonly used in practice of
rheumatology: Mechanisms of action, efficacay, and side effects. Seminars in
Arthritis and Rheumatism. 2005; 773-784.
17 De Silva V, Metwally A, Ernst E, Lewith G, Macfarlane G. Evidence for the
efficacy of complementary and alternative medicines in the management of
osteoarthritis: A systematic review. Rheumatology. 2011; 50: 911-920.
18 Lawrence RM. The natural solution for arthritis sufferers and athletes. Total
Health. 2004; 26(4): T24.
19 Appleton J. MSM joint health and beyond. Total Health. 2003; 25(1): S20-S21.
20 Nakhoostin-Roohi B, Barmaki S, Khoshkhahesh F, Bohlooli S. Effect of chronic
supplementation of MSM on oxidative stress following acute exercise in untrained
healthy men. J of Pharmacy & Pharmacology. 2011; 63: 1290-1294.
21 Pharmacy Update: Devil's claw. Chemist & Druggist. 2004; 19.
22 Wilkinson E. Review advises herbal remedies for back pain. Pulse. 2006; 14.
23 Mishra LC, Singh B. Scientific basis for therapeutic uses of guggul
commiphora mukul. Topics in Clin Chiro. 2000; 7(2): 51-56.
24 Craig W. Myrrh: Nature’s ancient anti-inflammatory agent. Vibrant Life. 2008;
25 Siemoneit U, Koeberle A, Rossi A, Dehm F, Verhoff M, Reckel S, Maier T, Jauch
J, Northoff H, Bernhard F, et al Inhibition of microsomal prostaglandin E2
synthase-1 as a molecular basis for the anti-inflammatory action of boswellic
acids from frankincense. 2011; 162: 147-162.
26 Tawab M, Werz O, Zsilavecz M. Boswellia serrata an overall assessment of in
vitro, preclinical and pharmacokinetic and clinical data. Clin Pharmacokinetics.
2011; 50(6): 349-369.
Grandma's Herbs Products
* These statements have not been
evaluated by the Food and Drug Administration. These products are not intended to
diagnose, treat, cure, or prevent any disease. This information is nutritional in nature
and should not be construed as medical advice. This notice is required by the Federal
Food, Drug and Cosmetic Act.
Copyright © 2014 Mindbodyhealth, LLC - All Rights Reserved
July 16, 2014